Refine Bone Marrow Decalcification Processes
This is where LeanDECAL comes in: an innovative tool that automates both the fixation and decalcification processes. By streamlining these processes, LeanDECAL not only expedites the work ow but also improves consistency and standardization, offering a faster, standardized, and more reliable alternative to traditional manual techniques.
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FIXATIVE TANK
for the fixation phase
RINSING TANK
DECALCIFIER TANK
SECOND RINSING / HOLDING TANK
TOUCHSCREEN TERMINAL
2 USB PORTS
CASSETTE CAVITY
WORKING AREA
DEDICATED RACK
Automatic process
LeanDECAL offers an automated and standardized approach to fixation and decalcification. Its setup includes a temperature-controlled processing cavity with an integrated magnetic stirrer, ensuring uniform reagent temperature distribution and consistent flow across the bone marrow surface. The system operates autonomously, dispensing reagents into the cavity and returning them to their designated tanks upon completion of each step. The operator only needs to select the most appropriate protocol for the specimens, guaranteeing reliable and standardized results with each cycle.
Enhanced Specimen Safety
- Temperature sensor: continuously monitors the reagent temperature.
- Reagent level sensors: control the reagent volume in the cavity.
- Cover sensor: monitors the secure closure of the cavity during runs.
- Specimen cavity filter: collects any potential residue.
- Spillage tray: located beneath the system, it collects any potential reagent spillages.
Additionally, the system keeps users informed reagents, providing timely alerts for replacements when necessary. Users can follow a guided procedure that includes scanning tank barcodes, ensuring full control and traceability.
Fast procedure
Full documentation
- Saved Runs
- Fixatives/decalcification solutions used
- Time and date of fixation/decalcification run
- Duration and temperature of fixation/decalcification phase
- Events log
- Reagents log
The perfect mate
Milestone has developed its own EDTA solution MoL-DECALCIFIER, based on a stoichiometric mixture of bibasic and tribasic EDTA to achieve a pH of 7.2-7.4 — the optimal range for faster decalcification — without requiring an acid/base buffer. MoL-DECALCIFIER perfectly complements LeanDECAL, as its interaction with controlled temperature and stirring of LeanDECAL facilitates the fixation, decalcification, and processing of bone marrow samples within a few hours.
Optimal quality
Through the use of standardized protocols and reagents specifically designed, optimal results are achieved without compromising tissue morphology or immunohistochemical analysis. Furthermore, even in molecular studies—which are now a cornerstone of diagnostic workflows—the use of EDTA- and other soft acid-based decalcifying agents has been shown to enhance both the quantity and quality of nucleic acids, preserving essential material for biomarker targeted therapies and gene expression profiling.
