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Histology Goes Green

Milestone is striving to improve the laboratory work environment by developing safer and greener reagents, for offering the best histological results joined to a granted compatibility to our units. Important steps in the histological biospecimens preparation, such as fixation, decalcification and processing use high volume of reagents. The full suite of Milestone reagents along with our product portfolio not only reduce the reagent consumption but aim to eliminate operators’ exposure to toxic reagents, such as xylene and formaldehyde, for a safer and more friendly laboratory environment.
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  • Greener
  • Fast Processes
  • Higher Safety
  • Tissue Processing


The Formalin Substitute
FineFIX is a patented formalin-free and water-based concentrate. When diluted with ethanol, its formulation of low toxicity additives overcomes the drawbacks commonly associated with the use of pure ethanol or ethanol-based fixatives (e.g. significant tissue shrinkage, vacuolization and pyknotic nuclei). FineFIX also provides optimal preservation of tissue antigens, nuclear and cytoplasmic morphology, and reduced lysis of red blood cells with preservation of the cytoplasmic membranes.
Available: Case of 4×1 gallons – Concentrate or Working Solution

UltraSAFE Fixative

UltraSAFE Fixative

10% Neutral Buffered Formalin
UltraSAFE Fixative comes in plastic containers, eliminating cardboard in the OR, and is perfectly suited to work with Milestone’s UltraSAFE formalin dispenser. Formalin is a fixation solution suitable for the preparation of routine histological specimens. It consists of 40% formaldehyde (4% w/w), diluted in distilled water at a 1/10 ratio and buffered to a pH of 7. As a fixative, Formalin provides the inactivation of the autolytic enzymes and bacteria that cause the putrefaction of tissues and the provision of structural stability to the chemical components of the protoplasm.

Available: Case of 2×2.5 gallon plastic containers

JFC Solution

JFC Solution

High Performance, Xylene-Free Processing Solution
JFC Solution is an innovative, patented solution composed of a mixture of ethanol, isopropanol, and a long-chain hydrocarbon. Under the influence of microwave heating, this solution becomes highly effective in the extraction of water and lipids from biological tissue in a single step, without the need for further dehydration or clearing. The miscibility of the three components of JFC Solution allows the performance of dehydration and clearing in a single step, representing a significant advantage over the conventional processing method.
Available: Case of 4×1 gallons



One-Step Dehydration and Clearing Solution
ProWAVE is Milestone’s proprietary blend of alcohols that provides one step dehydration and clearing. ProWAVE combines the advantages of ethanol and isopropyl in a single solution which is easy to use. The formulation reduces the possibility of over-processed and brittle tissues. ProWAVE is Xylene, Acetone, and Toluene Free! In addition, ProWAVE has a blue color indicator that signals when a reagent change is required with the added benefit of enhancing visualization of small samples using a light blue tint.
Available: Case of 4×1 gallons


Rack Cleaning Solution

Cleaning Solvent
Milestone Rack Cleaning Solution is a blend of isoparaffins that is specifically designed to safely work with the Milestone’s HistosMATE, automatic cleaning system. Moreover, it can be used in place of xylene for clearing during tissue processing, slide clearing and coverslip mounting. When heated, this solution becomes highly effective in the extraction of lipids from biological tissue. Rack Cleaning Solution is an almost odorless solvent and has the properties to dissolve fat and paraffin. Its formulation of low toxicity overcomes the drawbacks commonly associated with xylene, a hazardous product.
Available: Case of 4×1 gallons

Compatible with:
  • Decalcification


EDTA Based Decalcifying Solution
EDTA with a pH of 7.2-7.4 is the gold standard for decalcification to provide the best downstream testing. Milestone’s Mol-DECALCIFIER is a 10% unbuffered EDTA solution, based on a stoichiometric mixture of bibasic or tribasic EDTA to reach this pH value without the addition of an acid/base buffer. Pairing Milestone’s Mol-DECALCIFIER with increased temperature and agitation can allow complete bone marrow processing within 48 hours, while still producing better downstream testing results than other acid-based solutions.
Available: One gallon

  • Frozen Sections
    Frozen Sections


Milestone Cryoembedding Compound
MCC is a proprietary formulation of glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -40°C. Being water soluble, MCC doesn’t leave residue on the slides, eliminating nonspecific background staining. Additionally, MCC will not dull microtome knives.
Available: Case of 12×125 ml bottles

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