Automate, Standardize and Document your Decalcification Protocols
DecalMATE is an advanced automated system proficient in customizing fixation and decalcification procedures tailored specifically for bone specimens. By introducing groundbreaking automatic protocols to modern laboratories, it ensures heightened diagnostic precision, result uniformity, and expedited turnaround times.
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VENTED REAGENT CABINET
for safe operations
FIXATIVE TANK
to fix the bone sample
RINSING TANK
for the first rinsing between fixative and decalcifier
DECALCIFIER TANK
to decalcify the bone sample
SECOND RINSING/MAINTENANCE SOLUTION TANK
to rinse/ keep fresh the bone sample
EXHAUST
to guarantee safe protocols
WORK BOARD
to comfortably check the decalcification status
WORKING AREA
with acid resistant coating
2 USB PORTS
to download full process documentation
7’’ TOUCHSCREEN TERMINAL
to set and customize process parameters
FIXATION/DECALCIFICATION CAVITY
with a protective cover
Automatic and Standardized
DecalMATE provides an automated and standardized approach to fixation and decalcification. Its setup includes a temperature-controlled processing cavity and an integrated magnetic stirrer that ensures uniform reagent temperature distribution and consistent flow onto the bone surface.
The system runs autonomously through each step, dispensing reagents into the cavity and returning them to their designated tanks upon completion. The operator simply selects the most appropriate protocol for the sample, ensuring reliable results run after run. At the end of the protocol, a signal alerts the operator that the process is complete.
The system runs autonomously through each step, dispensing reagents into the cavity and returning them to their designated tanks upon completion. The operator simply selects the most appropriate protocol for the sample, ensuring reliable results run after run. At the end of the protocol, a signal alerts the operator that the process is complete.
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Here is an example of results achieved using MoL-DECALCIFIER. A control multiplex-PCR: amplification of different sized genomic segments (100,200,300,400 bp) harboring single-copy genes (Biomed-2) (Institute for Pathology Charité, Campus Mitte, Berlin, Germany).
M: size standard
1: Tonsil conventional
2, 4, 6: MoL-DECALCIEFIER
3, 5, 7: Conventional
1: Tonsil conventional
2, 4, 6: MoL-DECALCIEFIER
3, 5, 7: Conventional
Operator-Friendly
The software on the built-in touch screen guides the operator through the process.
Step 1
The operator simply places the rack, closes the protective cover and selects the desired protocol.
Step 2
The system automatically carries out all 4 phases (fixation, rinsing, decalcification and second rinsing) without the intervention of the operator.
Step 3
At completion, an alarm sounds, and the system automatically loads a maintenance solution. The built-in work board enables a quick check of the decalcified tissue.
The operator also benefits from extensive customization possibilities for the protocols:
- Temperature working range: 20-55°C
- Reagents: full compatibility with most fixative (FineFIX, Fomalin) and decalcification solutions (MoL-DECALCIFIER, EDTA 20% (max 50°C), formic acid 20% (max 50°C), acetic acid 20% (max 50°C), hydrochloric acid 10% (max 37°C), nitric acid 10% (max 37°C), trichloroacetic acid 10% (max 37°C).
- Rack: wide choice based on the sample’s requirements (Rack for 30 standard cassettes, Rack for 16 mega cassettes, Rack for 6 supermega cassettes, internal divider)
Safety
DecalMATE ensures the safe execution of fixation and decalcification protocols. Reagents are stored in tanks within a dedicated ventilated cabinet. The work surface is equipped with an exclusive protective cover and an exhaust system to remove potentially harmful vapors. The system includes safety sensors that continuously monitor reagent temperature.
An additional sensor on the cavity cover monitors its secure closure. This serves dual purposes: ensuring the operator’s safety when the reagent is hot and guaranteeing uniform heating of the reagent within the cavity. The reagent management system keeps users informed about reagent lifespan and provides timely alerts for replacements when necessary.
An additional sensor on the cavity cover monitors its secure closure. This serves dual purposes: ensuring the operator’s safety when the reagent is hot and guaranteeing uniform heating of the reagent within the cavity. The reagent management system keeps users informed about reagent lifespan and provides timely alerts for replacements when necessary.
Full Documentation
Through the software, every factor influencing the fixation and decalcification process is documented and stored in a logbook, which can be transferred to a USB stick and printed for quality assurance and compliance purposes. This includes:
- Type of fixatives/decalcification solutions used
- Time and date of fixation/decalcification run
- Fixation phase duration and temperature
- Decalcification phase duration and temperature
- Events Log
- Saved runs
