The Science of Cryoembedding for High-Quality Frozen Sections


It’s time to revolutionize the rapid freezing process

Breast and fatty tissues are some of the most difficult tissues to process as frozen sections. With PrestoCHILL, Milestone has developed a breakthrough freezing technology to overcome such limitations.

We combine a patented “face-down embedding” technique with a programmable -40°C cooling chamber to rapidly process high quality frozen sections of any type of tissue. No harmful nor dangerous reagents, such as liquid nitrogen, isopentane or dry ice, are used, so say goodbye to your worries over CAP deficiencies!

  • No freezing artifacts
  • 60 seconds freezing time
  • An all-dry system
  • Full downloadable documentation
  • No liquid nitrogen
  • No Co2 – No isopentane
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Lung Cancer 40x
Lung Cancer 40x
High Quality JPG
Breast Cancer 40x
Breast Cancer 40x
High Quality JPG

Thyroid 20x
High Quality JPG

Why PrestoCHILL?

    Standardized freezing at -40°C for all tissue types, even for those which are most difficult to cut at the cryostat (such as breast and lymph nodes). Rapidly change out molds with a range of different sizes and designs.
  • FAST
    Only 40 minutes to go from room temperature to the operating temperature of -40°C. At the set temperature, 6 biospecimens can be frozen simultaneously in only 60 seconds. Reduce trimming time by using Milestone’s cryoembedding compound (MCC).
  • SAFE
    No liquid nitrogen, no CO2, no isopentane. No operation inside the cryostat chamber during the freezing step. HEPA cap filter.
    The technologically advanced Stirling cooler uses Helium gas as a refrigerant in a sealed stainless steel chamber. No standard compressor is used, therefore no CFCs (Chlorofluorocarbons).
    A USB port enables both software updates and event log downloads.
    Its small footprint is suitable for lab environments which have limited space.

The perfect cryoembedding compound for the PrestoCHILL system

MCC is a proprietary formulation of glycols and resins specifically developed for optimal support during cryotomy of dissected tissues down to -40°C.

Being water soluble, MCC doesn’t leave residue on the slides, eliminating non specific background staining. Additionally, MCC will not dull microtome knives.


Have questions?