{"id":1503,"date":"2023-03-01T10:18:30","date_gmt":"2023-03-01T10:18:30","guid":{"rendered":"https:\/\/www.milestonemedsrl.com\/us\/?page_id=1503"},"modified":"2024-04-09T15:12:21","modified_gmt":"2024-04-09T15:12:21","slug":"decalmate","status":"publish","type":"page","link":"https:\/\/www.milestonemedsrl.com\/us\/products\/decalcification-and-fixation\/decalmate\/","title":{"rendered":"DecalMATE"},"content":{"rendered":"<div>\n<h3>DecalMATE<\/h3>\n<p><h4><strong>Automatic Fixation<br \/>and Decalcification System<\/strong><\/h4>\n<\/p>\n<div>\n<div class=\"uk-margin-top uk-visible@m\">\n<a class=\"uk-button uk-button-primary uk-margin-small-left\" href=\"#modal-form\" uk-toggle>Questions <span uk-icon=\"icon: question\"><\/span><\/a>\n<\/div>\n<div class=\"uk-margin-top uk-hidden@m\">\n<a class=\"uk-button uk-button-primary uk-margin-small-top\" href=\"#modal-form\" uk-toggle>Questions <span uk-icon=\"icon: question\"><\/span><\/a>\n<\/div>\n<div id=\"modal-form\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog uk-modal-body uk-margin-auto-vertical \">\n        <button class=\"uk-modal-close-outside\" type=\"button\" uk-close><\/button><\/p>\n<h3 class=\"uk-heading-bullet\">Have questions?<\/h3>\n\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: \"d966b92c-3341-49c7-b285-c39e778f6e16\",\n\t\t\t\t\t\t\t\t\ttarget: \"#hbspt-form-1776389082000-0426663896\",\n\t\t\t\t\t\t\t\t\tregion: \"na1\",\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t})});\n\t\t\t\t\t\t<\/script>\n\t\t\t\t\t\t<div class=\"hbspt-form\" id=\"hbspt-form-1776389082000-0426663896\"><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3>Automate, Standardize and Document your Decalcification Protocols<br \/>\n<\/h3>\n<div>DecalMATE is an advanced automated system proficient in <strong>customizing fixation and decalcification procedures<\/strong> tailored specifically for bone specimens. By introducing groundbreaking automatic protocols to modern laboratories, it ensures heightened diagnostic precision, result uniformity, and expedited turnaround times.<\/div>\n<ul>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/11\/icon-ergonomics.png\" alt=\"Automatic &#038; Standardized\"><\/p>\n<p><a href=\"#automatic\">Automatic &#038; Standardized<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/04\/icon-quality.png\" alt=\"Optimal Results\"><\/p>\n<p><a href=\"#results\">Optimal Results<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"https:\/\/www.milestonemedsrl.com\/wp-content\/uploads\/2023\/12\/icon-user-oriented.png\" alt=\"Operator-friendly\"><\/p>\n<p><a href=\"#operator\">Operator-friendly<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/11\/icon-user-safety-1.png\" alt=\"Safety\"><\/p>\n<p><a href=\"#safety-decalmate\">Safety<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"https:\/\/www.milestonemedsrl.com\/wp-content\/uploads\/2023\/09\/complete-documentation.png\" alt=\"Full Documentation\"><\/p>\n<p><a href=\"#documentation\">Full Documentation<\/a><\/p>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<div><a class=\"uk-button uk-button-default\" href=\"#modal-quote\" uk-toggle>Request a quote <span uk-icon=\"icon: file-edit\"><\/span><\/a><\/p>\n<div id=\"modal-quote\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog uk-modal-body uk-margin-auto-vertical\">\n        \t<button class=\"uk-modal-close-outside\" type=\"button\" uk-close><\/button><\/p>\n<h3 class=\"uk-heading-bullet\">Request a quote<\/h3>\n\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: \"f82ecb38-b753-4c96-b0da-a94dbda82e2d\",\n\t\t\t\t\t\t\t\t\ttarget: \"#hbspt-form-1776389082000-2413902310\",\n\t\t\t\t\t\t\t\t\tregion: \"na1\",\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t})});\n\t\t\t\t\t\t<\/script>\n\t\t\t\t\t\t<div class=\"hbspt-form\" id=\"hbspt-form-1776389082000-2413902310\"><\/div><\/div>\n<\/div>\n<\/div>\n<\/li>\n<li>\n<div><a class=\"uk-button uk-button-default\" href=\"\/us\/wp-content\/uploads\/sites\/3\/2024\/04\/DecalMATE_Brochure_USA.pdf\">View Brochure <span uk-icon=\"icon: file-text\"><\/span><\/a><\/div>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/decalmate-unit.jpg\" alt=\"DecalMATE Automatic fixation and decalcification system\"><\/p>\n<ul>\n<li>\n<h3>VENTED REAGENT CABINET<\/h3>\n<div>for safe operations<\/div>\n<\/li>\n<li>\n<h3>FIXATIVE TANK<\/h3>\n<div>to fix the bone sample<\/div>\n<\/li>\n<li>\n<h3>RINSING TANK<\/h3>\n<div>for the first rinsing between fixative and decalcifier\n<\/div>\n<\/li>\n<li>\n<h3>DECALCIFIER TANK<\/h3>\n<div>to decalcify the bone sample\n<\/div>\n<\/li>\n<li>\n<h3>SECOND RINSING\/MAINTENANCE SOLUTION TANK<\/h3>\n<div>to rinse\/ keep fresh the bone sample\n<\/div>\n<\/li>\n<li>\n<h3>EXHAUST<\/h3>\n<div>to guarantee safe protocols<\/div>\n<\/li>\n<li>\n<h3>WORK BOARD <\/h3>\n<div>to comfortably check the decalcification status<\/div>\n<\/li>\n<li>\n<h3>WORKING AREA<\/h3>\n<div>with acid resistant coating<\/div>\n<\/li>\n<li>\n<h3>2 USB PORTS<\/h3>\n<div>to download full process documentation\n<\/div>\n<\/li>\n<li>\n<h3>7\u2019\u2019 TOUCHSCREEN TERMINAL<\/h3>\n<div>to set and customize process parameters<\/div>\n<\/li>\n<li>\n<h3>FIXATION\/DECALCIFICATION CAVITY<\/h3>\n<div>with a protective cover<\/div>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/AutomatcStandardized.jpg\" alt=\"Automatc and Standardized\"><\/p>\n<div>\n<h3>Automatic and Standardized<\/h3>\n<div>DecalMATE provides an <strong>automated and standardized approach to fixation and decalcification<\/strong>. Its setup includes a temperature-controlled processing cavity and an integrated magnetic stirrer that ensures uniform reagent temperature distribution and consistent flow onto the bone surface.<br \/><strong>The system runs autonomously through each step<\/strong>, dispensing reagents into the cavity and returning them to their designated tanks upon completion. The operator simply selects the most appropriate protocol for the sample, ensuring reliable results run after run. At the end of the protocol, a signal alerts the operator that the process is complete.<\/div>\n<\/div>\n<div><a class=\"uk-button uk-button-default\" href=\"#modal-demo\" uk-toggle>Request a Virtual Demo <span uk-icon=\"icon: video-camera\"><\/span><\/a><\/p>\n<div id=\"modal-demo\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog uk-modal-body uk-margin-auto-vertical\">\n        \t<button class=\"uk-modal-close-outside\" type=\"button\" uk-close><\/button><\/p>\n<h3 class=\"uk-heading-bullet\">Request a Virtual Demo<\/h3>\n\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: \"f30be08d-9da6-4f57-8817-6b0dcaba2a66\",\n\t\t\t\t\t\t\t\t\ttarget: \"#hbspt-form-1776389082000-5440013448\",\n\t\t\t\t\t\t\t\t\tregion: \"na1\",\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t})});\n\t\t\t\t\t\t<\/script>\n\t\t\t\t\t\t<div class=\"hbspt-form\" id=\"hbspt-form-1776389082000-5440013448\"><\/div><\/div>\n<\/div>\n<\/div>\n<h3>Optimal Results<\/h3>\n<div>\n<div>Recent reports have systematically <strong>investigated the effects of various fixation and decalcification agents<\/strong> on the quantity and quality of RNA and DNA recovered from bone biopsies. These reports concluded that <strong>the RNA and DNA yield and integrity are significantly reduced<\/strong> when strong acids (hydrochloric, nitric) are used in comparison with 12,5-14% EDTA and formic acid.<\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th>Fixatives<\/th>\n<th>DNA &#8211; Yield (ng)<\/th>\n<th>RNA &#8211; Yield (ng)<\/th>\n<th>Decal Time<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>14% EDTA<\/td>\n<td>67.8<\/td>\n<td>226.2<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>Formic<\/td>\n<td>41.5<\/td>\n<td>175.0<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>HNO<sub>3<\/sub><\/td>\n<td>11.4<\/td>\n<td>51.7<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>HCL\/EDTA<\/td>\n<td>5.3<\/td>\n<td>30.5<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><i>Analysis of the effect of various decalcification agents on the quality and quantity of nucleic acid (DNA and RNA) recovered from bone biopsies &#8211; Veena M. Singh et al. (2013) <\/i><\/p>\n<\/div>\n<div>\n<div>The studies show that <strong>the use of either EDTA or formic acid as \u201csoft\u201d decalcifiers is preferred<\/strong>, as they are more suitable for molecular studies. Moreover, it has been noticed that the use of EDTA at a pH range of 7.2-7.4 further expedited the decalcification. Milestone <a href=\"\/us\/products\/reagents\/#decalcification\"> MoL-DECALCIFIER<\/a> allows this pH to be achieved without the need for an additional acid\/base buffer by using an innovative pure EDTA solution based on a stoichiometric mixture of bibasic and tribasic EDTA. <strong>The combination of MoL-DECALCIFIER, temperature management and stirring function featured in the DecalMATE significantly reduces decalcification times.<\/strong>\n<\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th>Fixation<\/th>\n<th>Decalcification<\/th>\n<th>Temperature<\/th>\n<th>Total Time<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Formalin 10%<\/td>\n<td>MoL-DECALCIFIER<\/td>\n<td>\u00b0C<\/td>\n<td>Fixation + Decalcification<\/td>\n<\/tr>\n<tr>\n<td>4h<\/td>\n<td>36h<\/td>\n<td>27<\/td>\n<td>40h<\/td>\n<\/tr>\n<tr>\n<td>1h 30\u2019<\/td>\n<td>16h 30\u2019<\/td>\n<td>37<\/td>\n<td>18h<\/td>\n<\/tr>\n<tr>\n<td>1h<\/td>\n<td>4h<\/td>\n<td>50<\/td>\n<td>5h<\/td>\n<\/tr>\n<tr>\n<td>Formalin 10%<\/td>\n<td>Formic 10%<\/td>\n<td>\u00b0C<\/td>\n<td>Fixation + Decalcification<\/td>\n<\/tr>\n<tr>\n<td>4h<\/td>\n<td>4h<\/td>\n<td>27<\/td>\n<td>8h<\/td>\n<\/tr>\n<tr>\n<td>1h 30\u2019<\/td>\n<td>1h 30\u2019<\/td>\n<td>37<\/td>\n<td>3h<\/td>\n<\/tr>\n<tr>\n<td>1h<\/td>\n<td>4h<\/td>\n<td>50<\/td>\n<td>2h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><i>DecalMATE typical protocols for bone marrows (\u00d8 1.8mm)<\/i><\/p>\n<\/div>\n<div>Here is an example of results achieved using <a href=\"\/us\/products\/reagents\/#decalcification\"> MoL-DECALCIFIER<\/a>. A control multiplex-PCR: amplification of different sized genomic segments (100,200,300,400 bp) harboring single-copy genes (Biomed-2) (Institute for Pathology Charit\u00e9, Campus Mitte, Berlin, Germany).<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/01\/tonsil.png\" alt=\"Control multiplex-PCR\"><\/p>\n<div>M: size standard<br \/>\n1: Tonsil conventional<br \/>\n<strong>2, 4, 6: MoL-DECALCIEFIER<\/strong><br \/>\n3, 5, 7: Conventional<\/div>\n<h3>Operator-Friendly<\/h3>\n<div>The software on the built-in touch screen guides the operator through the process. <\/div>\n<ul>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/step1-1.jpg\" alt=\"Operator-Friendly - Step 1\"><\/p>\n<h3>Step 1<\/h3>\n<div>The operator simply places the rack, closes the protective cover and selects the desired protocol.<\/div>\n<\/li>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/step2-1.jpg\" alt=\"Operator-Friendly - Step 2\"><\/p>\n<h3>Step 2<\/h3>\n<div>The system automatically carries out all 4 phases (fixation, rinsing, decalcification and second rinsing) without the intervention of the operator.<\/div>\n<\/li>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/step3-1.jpg\" alt=\"Operator-Friendly - Step 3\"><\/p>\n<h3>Step 3<\/h3>\n<div>At completion, an alarm sounds, and the system automatically loads a maintenance solution. The built-in work board enables a quick check of the decalcified tissue.<\/div>\n<\/li>\n<\/ul>\n<div>The operator also benefits from extensive customization possibilities for the protocols:<br \/>\n<\/p>\n<ul class=\"uk-list uk-list-divider uk-list-collapse\">\n<li><span uk-icon=\"icon: check\"><\/span> Temperature working range: 20-55\u00b0C<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Reagents: full compatibility with most fixative (<a href=\"\/us\/products\/reagents\/#processing\">FineFIX<\/a>, Fomalin) and decalcification solutions (<a href=\"\/us\/products\/reagents\/#decalcification\">MoL-DECALCIFIER<\/a>, EDTA 20% (max 50\u00b0C), formic acid 20% (max 50\u00b0C), acetic acid 20% (max 50\u00b0C), hydrochloric acid 10% (max 37\u00b0C), nitric acid 10% (max 37\u00b0C), trichloroacetic acid 10% (max 37\u00b0C).<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Rack: wide choice based on the sample\u2019s requirements (Rack for 30 standard cassettes, Rack for 16 mega cassettes, Rack for 6 supermega cassettes, internal divider)<\/li>\n<\/ul>\n<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/safety-1.jpg\" alt=\"Safety\"><\/p>\n<div>\n<h3>Safety<\/h3>\n<div>DecalMATE ensures the safe execution of fixation and decalcification protocols. Reagents are stored in tanks within a dedicated ventilated cabinet. The work surface is equipped with an <strong>exclusive protective cover and an exhaust system<\/strong> to remove potentially harmful vapors. The system includes safety sensors that continuously monitor reagent temperature.<br \/> An additional sensor on the cavity cover monitors its secure closure. This serves dual purposes: ensuring the operator&#8217;s safety when the reagent is hot and guaranteeing uniform heating of the reagent within the cavity.<br \/>\nThe reagent management system keeps users informed about reagent lifespan and provides <strong>timely alerts for replacements<\/strong> when necessary.<\/div>\n<\/div>\n<hr>\n<div>\n<h3>Full Documentation<\/h3>\n<div>Through the software, every factor influencing the fixation and decalcification process is <strong>documented and stored in a logbook<\/strong>, which can be transferred to a USB stick and printed for quality assurance and compliance purposes. This includes:<br \/>\n<\/p>\n<ul class=\"uk-list uk-list-divider uk-list-collapse\">\n<li><span uk-icon=\"icon: check\"><\/span> Type of fixatives\/decalcification solutions used<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Time and date of fixation\/decalcification run<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Fixation phase duration and temperature<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Decalcification phase duration and temperature<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Events Log<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Saved runs<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/documentation-1.jpg\" alt=\"Full Documentation\"><\/p>\n<h2>Related products<\/h2>\n<h2>Resources<\/h2>\n<ul>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/03\/icon-webinar-green.png\" alt=\"Webinar\"><\/p>\n<h3>Webinars  <span uk-icon=\"icon: arrow-right\"><\/span><\/h3>\n<p><a href=\"\/us\/webinars\/#decalcification\">Read More<\/a><\/p>\n<\/li>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/03\/icon-publication-green.png\" alt=\"Publication\"><\/p>\n<h3>Publications  <span uk-icon=\"icon: arrow-right\"><\/span><\/h3>\n<p><a href=\"\/us\/publications\/#decalcification\">Read More<\/a><\/p>\n<\/li>\n<li>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/03\/icon-casestudy-green.png\" alt=\"Case Study\"><\/p>\n<h3>Case Study <span uk-icon=\"icon: arrow-right\"><\/span><\/h3>\n<p><a href=\"\/us\/case-study\/\">Read More<\/a><\/p>\n<\/li>\n<\/ul>\n<h2>Have questions?<\/h2>\n<div>Contact us directly by completing the form below.<\/div>\n<div>\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: 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100px;}\\n\\n.el-element {background-color: rgba(0,0,0,0.3)}\\n\\n.uk-button {color: #000;}\",\"icon\":\"\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"default\",\"link_text\":\"\",\"margin\":\"default\",\"meta\":\"\n\n<h4><strong>Automatic Fixation<br \\\/>and Decalcification System<\\\/strong><\\\/h4>\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_padding\":\"default\",\"panel_style\":\"card-primary\",\"title\":\"DecalMATE\",\"title_align\":\"top\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h1\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"2-3\"}}]}],\"name\":\"Hero\"},{\"type\":\"section\",\"props\":{\"animation\":\"slide-top-medium\",\"id\":\"solutions\",\"image_position\":\"center-center\",\"padding_remove_bottom\":false,\"padding_remove_top\":false,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"xlarge\"},\"children\":[{\"type\":\"row\",\"props\":{\"layout\":\"1-2,1-2\",\"margin\":\"large\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"headline\",\"props\":{\"content\":\"Automate, Standardize and Document your Decalcification Protocols\\n\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_style\":\"h3\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"DecalMATE is an advanced automated system proficient in <strong>customizing fixation and decalcification procedures<\\\/strong> tailored specifically for bone specimens. 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Veena M. 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(2013) <\\\/i><\\\/p>\",\"margin\":\"default\",\"maxwidth\":\"xlarge\",\"text_align\":\"center\",\"text_style\":\"small\"},\"name\":\"*frase Decal\"}]}]}]}]}]},{\"type\":\"row\",\"props\":{\"css\":\".uk-tile-muted {background-color: rgba(0, 0, 0, 0.1); border-radius: 20px;}\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"style\":\"tile-muted\"},\"children\":[{\"type\":\"fragment\",\"props\":{\"css\":\".uk-tile-muted {background-color: rgba(0, 0, 0, 0.1); border-radius: 20px;}\",\"margin\":\"default\"},\"children\":[{\"type\":\"row\",\"props\":{\"layout\":\"1-3,2-3\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"panel\",\"props\":{\"block_align\":\"center\",\"content\":\"The studies show that <strong>the use of either EDTA or formic acid as \\u201csoft\\u201d decalcifiers is preferred<\\\/strong>, as they are more suitable for molecular studies. 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Milestone <a href=\\\"products\\\/reagents\\\/#decalcification\\\"> MoL-DECALCIFIER<\\\/a> allows this pH to be achieved without the need for an additional acid\\\/base buffer by using an innovative pure EDTA solution based on a stoichiometric mixture of bibasic and tribasic EDTA. <strong>The combination of MoL-DECALCIFIER, temperature management and stirring function featured in the DecalMATE significantly reduces decalcification times.<\\\/strong>\\n\",\"content_column_breakpoint\":\"m\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"maxwidth\":\"xlarge\",\"meta\":\"\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"2-3\"},\"children\":[{\"type\":\"fs_table\",\"props\":{\"block_align\":\"center\",\"css\":\".el-element th {font-weight: bold; font-size: 16px;}\\n\\nthead {background-color: rgba(0, 0, 0, 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page _PAGE_ of _PAGES_\",\"table_datatables_translation_infoEmpty\":\"No records available\",\"table_datatables_translation_infoFiltered\":\"(filtered from _MAX_ total records)\",\"table_datatables_translation_lengthMenu\":\"Display _MENU_ records per page\",\"table_datatables_translation_pagination_next\":\"Next\",\"table_datatables_translation_pagination_previous\":\"Previous\",\"table_datatables_translation_search\":\"Search\",\"table_datatables_translation_zeroRecords\":\"Nothing found - sorry\",\"table_head_image\":\"Image\",\"table_head_link\":\"Link\",\"table_head_text_1\":\"Fixation\",\"table_head_text_2\":\"Decalcification\",\"table_head_text_3\":\"Temperature\",\"table_head_text_4\":\"Total Time\",\"table_head_text_5\":\"Text 5\",\"table_head_text_6\":\"Text 6\",\"table_head_text_7\":\"Text 7\",\"table_head_text_8\":\"Text 8\",\"table_head_text_9\":\"Text 9\",\"table_head_title\":\"Standard\",\"table_hover\":true,\"table_justify\":false,\"table_meta\":\"\",\"table_meta_color\":\"primary\",\"table_meta_decoration\":\"divider\",\"table_meta_element\":\"div\",\"table_meta_limit_length\":\"80\",\"table_meta_margin\":\"remove\",\"table_meta_position\":\"below-table-title\",\"table_meta_style\":\"h3\",\"table_order\":\"4\",\"table_responsive\":\"overflow\",\"table_size\":\"small\",\"table_style\":\"divider\",\"table_title\":\"\",\"table_title_element\":\"h2\",\"table_title_grid_breakpoint\":\"m\",\"table_title_grid_width\":\"1-2\",\"table_title_limit_length\":\"80\",\"table_title_position\":\"top\",\"table_vertical_align\":true,\"table_width_image\":\"shrink\",\"table_width_image_custom\":\"100\",\"table_width_link\":\"shrink\",\"table_width_link_custom\":\"100\",\"table_width_text_1\":\"shrink\",\"table_width_text_1_custom\":\"100\",\"table_width_text_2\":\"shrink\",\"table_width_text_2_custom\":\"100\",\"table_width_text_3\":\"shrink\",\"table_width_text_3_custom\":\"100\",\"table_width_text_4\":\"shrink\",\"table_width_text_4_custom\":\"100\",\"table_width_text_5\":\"shrink\",\"table_width_text_5_custom\":\"100\",\"table_width_text_6\":\"shrink\",\"table_width_text_6_custom\":\"100\",\"table_width_text_7\":\"shrink\",\"table_width_text_7_custom\":\"100\",\"table_width_text_8\":\"shrink\",\"table_width_text_8_custom\":\"100\",\"table_width_text_9\":\"shrink\",\"table_width_text_9_custom\":\"100\",\"table_width_title\":\"shrink\",\"table_width_title_custom\":\"100\",\"text_1_align\":\"center\",\"text_1_limit_length\":\"10\",\"text_1_style\":\"h5\",\"text_2_align\":\"center\",\"text_2_limit_length\":\"20\",\"text_2_style\":\"h5\",\"text_3_align\":\"center\",\"text_3_limit_length\":\"30\",\"text_3_style\":\"h5\",\"text_4_align\":\"center\",\"text_4_limit_length\":\"40\",\"text_4_style\":\"h5\",\"text_5_align\":\"center\",\"text_5_limit_length\":\"50\",\"text_5_style\":\"h5\",\"text_6_align\":\"center\",\"text_6_limit_length\":\"60\",\"text_6_style\":\"h5\",\"text_7_align\":\"center\",\"text_7_limit_length\":\"70\",\"text_7_style\":\"h5\",\"text_8_align\":\"center\",\"text_8_limit_length\":\"80\",\"text_8_style\":\"h5\",\"text_9_align\":\"center\",\"text_9_limit_length\":\"80\",\"text_9_style\":\"h5\",\"title_limit_length\":\"80\",\"title_style\":\"h5\"},\"children\":[{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"Formalin 10%\",\"text_2\":\"MoL-DECALCIFIER\",\"text_3\":\"\\u00b0C\",\"text_4\":\"Fixation + Decalcification\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"4h\",\"text_2\":\"36h\",\"text_3\":\"27\",\"text_4\":\"40h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h 30\\u2019\",\"text_2\":\"16h 30\\u2019\",\"text_3\":\"37\",\"text_4\":\"18h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h\",\"text_2\":\"4h\",\"text_3\":\"50\",\"text_4\":\"5h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"Formalin 10%\",\"text_2\":\"Formic 10%\",\"text_3\":\"\\u00b0C\",\"text_4\":\"Fixation + Decalcification\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"4h\",\"text_2\":\"4h\",\"text_3\":\"27\",\"text_4\":\"8h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h 30\\u2019\",\"text_2\":\"1h 30\\u2019\",\"text_3\":\"37\",\"text_4\":\"3h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h\",\"text_2\":\"4h\",\"text_3\":\"50\",\"text_4\":\"2h\",\"title\":\"\"}}]},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p><i>DecalMATE typical protocols for bone marrows (\\u00d8 1.8mm)<\\\/i><\\\/p>\",\"margin\":\"default\",\"text_align\":\"center\",\"text_style\":\"small\"}}]}]}]}]}]},{\"type\":\"row\",\"props\":{\"column_gap\":\"medium\",\"id\":\"safety\",\"layout\":\"1-2,1-2\",\"margin\":\"large\",\"margin_remove_top\":false,\"row_gap\":\"large\",\"vertical_align\":true},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"text\",\"props\":{\"block_align\":\"center\",\"column_breakpoint\":\"m\",\"content\":\"Here is an example of results achieved using <a href=\\\"products\\\/reagents\\\/#decalcification\\\"> MoL-DECALCIFIER<\\\/a>. A control multiplex-PCR: amplification of different sized genomic segments (100,200,300,400 bp) harboring single-copy genes (Biomed-2) (Institute for Pathology Charit\\u00e9, Campus Mitte, Berlin, Germany).\",\"margin\":\"default\",\"maxwidth\":\"2xlarge\",\"text_align\":\"left\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"image\",\"props\":{\"image\":\"wp-content\\\/uploads\\\/2024\\\/01\\\/tonsil.png\",\"image_alt\":\"Control multiplex-PCR\",\"image_svg_color\":\"emphasis\",\"image_width\":\"600\",\"margin\":\"default\",\"text_align\":\"center\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"M: size standard<br \\\/>\\n1: Tonsil conventional<br \\\/>\\n<strong>2, 4, 6: MoL-DECALCIEFIER<\\\/strong><br \\\/>\\n3, 5, 7: Conventional\",\"margin\":\"default\",\"text_align\":\"center\",\"text_style\":\"small\"}}]}]}]},{\"type\":\"section\",\"props\":{\"animation\":\"slide-bottom-medium\",\"animation_delay\":\"100\",\"image_position\":\"center-center\",\"style\":\"muted\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"xlarge\"},\"children\":[{\"type\":\"row\",\"props\":{\"id\":\"operator\",\"match\":false,\"width\":\"xlarge\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"headline\",\"props\":{\"content\":\"Operator-Friendly\",\"id\":\"operator\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_style\":\"h3\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"The software on the built-in touch screen guides the operator through the process. \",\"margin\":\"default\"}},{\"type\":\"grid\",\"props\":{\"content_column_breakpoint\":\"m\",\"css\":\".el-title {text-transform: uppercase;}\",\"filter_align\":\"left\",\"filter_all\":true,\"filter_grid_breakpoint\":\"m\",\"filter_grid_width\":\"auto\",\"filter_position\":\"top\",\"filter_style\":\"tab\",\"grid_column_align\":false,\"grid_column_gap\":\"medium\",\"grid_default\":\"1\",\"grid_medium\":\"3\",\"grid_row_align\":false,\"icon_width\":80,\"image_align\":\"between\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"item_animation\":true,\"item_maxwidth\":\"xlarge\",\"link_margin\":\"medium\",\"link_style\":\"default\",\"link_text\":\"Read more\",\"margin\":\"default\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_image_no_padding\":false,\"panel_padding\":\"default\",\"panel_style\":\"card-default\",\"parallax_easing\":\"-2\",\"parallax_y\":\"-40\",\"position\":\"relative\",\"position_z_index\":\"1\",\"show_content\":true,\"show_image\":true,\"show_link\":true,\"show_meta\":true,\"show_title\":true,\"title_align\":\"top\",\"title_decoration\":\"line\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h4\"},\"children\":[{\"type\":\"grid_item\",\"props\":{\"content\":\"The operator simply places the rack, closes the protective cover and selects the desired protocol.\",\"icon\":\"\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/step1-1.jpg\",\"image_alt\":\"Operator-Friendly - Step 1\",\"link_text\":\"Read Brochure <span uk-icon=\\\"icon: arrow-right\\\"><\\\/span>\",\"panel_style\":\"card-default\",\"title\":\"Step 1\"}},{\"type\":\"grid_item\",\"props\":{\"content\":\"The system automatically carries out all 4 phases (fixation, rinsing, decalcification and second rinsing) without the intervention of the operator.\",\"icon\":\"\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/step2-1.jpg\",\"image_alt\":\"Operator-Friendly - Step 2\",\"link_text\":\"Read Brochure <span uk-icon=\\\"icon: arrow-right\\\"><\\\/span>\",\"panel_style\":\"card-default\",\"title\":\"Step 2\"}},{\"type\":\"grid_item\",\"props\":{\"content\":\"At completion, an alarm sounds, and the system automatically loads a maintenance solution. The built-in work board enables a quick check of the decalcified tissue.\",\"icon\":\"\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/step3-1.jpg\",\"image_alt\":\"Operator-Friendly - Step 3\",\"link_text\":\"Read Brochure <span uk-icon=\\\"icon: arrow-right\\\"><\\\/span>\",\"panel_style\":\"card-default\",\"title\":\"Step 3\"}}]},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"The operator also benefits from extensive customization possibilities for the protocols:\\n<br \\\/>\\n\n\n<ul class=\\\"uk-list uk-list-divider uk-list-collapse\\\">\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Temperature working range: 20-55\\u00b0C<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Reagents: full compatibility with most fixative (<a href=\\\"products\\\/reagents\\\/#processing\\\">FineFIX<\\\/a>, Fomalin) and decalcification solutions (<a href=\\\"products\\\/reagents\\\/#decalcification\\\">MoL-DECALCIFIER<\\\/a>, EDTA 20% (max 50\\u00b0C), formic acid 20% (max 50\\u00b0C), acetic acid 20% (max 50\\u00b0C), hydrochloric acid 10% (max 37\\u00b0C), nitric acid 10% (max 37\\u00b0C), trichloroacetic acid 10% (max 37\\u00b0C).<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Rack: wide choice based on the sample\\u2019s requirements (Rack for 30 standard cassettes, Rack for 16 mega cassettes, Rack for 6 supermega cassettes, internal divider)<\\\/li>\\n<\\\/ul>\",\"margin\":\"default\"}}]}]}],\"name\":\"operator friendly\"},{\"name\":\"safety - documentation\",\"type\":\"section\",\"props\":{\"animation\":\"slide-left-medium\",\"image_position\":\"center-center\",\"image_size\":\"cover\",\"padding_remove_top\":false,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"xlarge\"},\"children\":[{\"type\":\"row\",\"props\":{\"column_gap\":\"medium\",\"id\":\"safety-decalmate\",\"layout\":\"1-2,1-2\",\"margin\":\"medium\",\"margin_remove_bottom\":false,\"row_gap\":\"large\",\"vertical_align\":true},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"image\",\"props\":{\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/safety-1.jpg\",\"image_alt\":\"Safety\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"order_first\":\"m\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"panel\",\"props\":{\"block_align\":\"center\",\"block_align_breakpoint\":\"m\",\"content\":\"DecalMATE ensures the safe execution of fixation and decalcification protocols. Reagents are stored in tanks within a dedicated ventilated cabinet. The work surface is equipped with an <strong>exclusive protective cover and an exhaust system<\\\/strong> to remove potentially harmful vapors. The system includes safety sensors that continuously monitor reagent temperature.<br \/> An additional sensor on the cavity cover monitors its secure closure. This serves dual purposes: ensuring the operator's safety when the reagent is hot and guaranteeing uniform heating of the reagent within the cavity.\\nThe reagent management system keeps users informed about reagent lifespan and provides <strong>timely alerts for replacements<\\\/strong> when necessary.\",\"content_column_breakpoint\":\"m\",\"icon_width\":80,\"id\":\"digitalize\",\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"maxwidth\":\"xlarge\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"Safety\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}}]}]},{\"type\":\"row\",\"props\":{\"margin\":\"medium\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\"},\"children\":[{\"type\":\"divider\",\"props\":{\"divider_element\":\"hr\",\"visibility\":\"hidden-m\"},\"name\":\"Divider for small display\"}]}]},{\"type\":\"row\",\"props\":{\"column_gap\":\"medium\",\"id\":\"documentation\",\"layout\":\"1-2,1-2\",\"margin\":\"medium\",\"margin_remove_top\":false,\"row_gap\":\"large\",\"vertical_align\":true},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"panel\",\"props\":{\"block_align\":\"center\",\"block_align_breakpoint\":\"m\",\"content\":\"Through the software, every factor influencing the fixation and decalcification process is <strong>documented and stored in a logbook<\\\/strong>, which can be transferred to a USB stick and printed for quality assurance and compliance purposes. This includes:\\n<br \\\/>\\n\n\n<ul class=\\\"uk-list uk-list-divider uk-list-collapse\\\">\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Type of fixatives\\\/decalcification solutions used<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Time and date of fixation\\\/decalcification run<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Fixation phase duration and temperature<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Decalcification phase duration and temperature<\\\/li>\\n     \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Events Log<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Saved 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Automate, Standardize and Document your Decalcification Protocols DecalMATE is an advanced automated system proficient in customizing fixation and decalcification procedures tailored specifically for bone specimens. By introducing groundbreaking automatic protocols to modern laboratories, it ensures heightened diagnostic precision, result uniformity, and expedited turnaround times. Automatic &#038; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1497,"menu_order":13,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"content-type":"","footnotes":""},"folder":[],"class_list":["post-1503","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v22.5) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DecalMATE | Milestone Medical<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.milestonemedsrl.com\/us\/products\/decalcification-and-fixation\/decalmate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DecalMATE\" \/>\n<meta property=\"og:description\" content=\"DecalMATE Automatic Fixationand Decalcification System Questions Questions Have questions? Automate, Standardize and Document your Decalcification Protocols DecalMATE is an advanced automated system proficient in customizing fixation and decalcification procedures tailored specifically for bone specimens. By introducing groundbreaking automatic protocols to modern laboratories, it ensures heightened diagnostic precision, result uniformity, and expedited turnaround times. 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