{"id":1500,"date":"2023-03-01T10:17:35","date_gmt":"2023-03-01T10:17:35","guid":{"rendered":"https:\/\/www.milestonemedsrl.com\/us\/?page_id=1500"},"modified":"2024-04-09T15:13:21","modified_gmt":"2024-04-09T15:13:21","slug":"bonestation","status":"publish","type":"page","link":"https:\/\/www.milestonemedsrl.com\/us\/products\/decalcification-and-fixation\/bonestation\/","title":{"rendered":"BoneSTATION"},"content":{"rendered":"<div>\n<h3>BoneSTATION<\/h3>\n<p><h4><strong>Advanced System for Fixation and Decalcification of Bone Tissues<\/strong><\/h4>\n<\/p>\n<div>\n<div class=\"uk-margin-top uk-visible@m\">\n<a class=\"uk-button uk-button-primary uk-margin-small-left\" href=\"#modal-form\" uk-toggle>Questions <span uk-icon=\"icon: question\"><\/span><\/a>\n<\/div>\n<div class=\"uk-margin-top uk-hidden@m\">\n<a class=\"uk-button uk-button-primary uk-margin-small-top\" href=\"#modal-form\" uk-toggle>Questions <span uk-icon=\"icon: question\"><\/span><\/a>\n<\/div>\n<div id=\"modal-form\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog uk-modal-body uk-margin-auto-vertical \">\n        <button class=\"uk-modal-close-outside\" type=\"button\" uk-close><\/button><\/p>\n<h3 class=\"uk-heading-bullet\">Have questions?<\/h3>\n\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: \"d966b92c-3341-49c7-b285-c39e778f6e16\",\n\t\t\t\t\t\t\t\t\ttarget: \"#hbspt-form-1778694925000-4339175898\",\n\t\t\t\t\t\t\t\t\tregion: \"na1\",\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t})});\n\t\t\t\t\t\t<\/script>\n\t\t\t\t\t\t<div class=\"hbspt-form\" id=\"hbspt-form-1778694925000-4339175898\"><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<h3>Optimized and Efficient Bone Marrow Decalcification<br \/>\n<\/h3>\n<div>BoneSTATION is an innovative workstation designed for comprehensive control over the pre-analytical steps of bone tissues. It utilizes two work areas, one <strong>dedicated to the fixation process and<\/strong> another for the <strong>decalcification step<\/strong>, complete with glass dishes. This system accelerates the overall process while ensuring the attainment of diagnostic results for both morphological and molecular studies.\n<\/div>\n<ul>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/11\/icon-ergonomics.png\" alt=\"Controlled Processes\"><\/p>\n<p><a href=\"#process\">Controlled Processes<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/04\/icon-workflow.png\" alt=\"Productivity and Optimization\"><\/p>\n<p><a href=\"#productivity\">Productivity and Optimization<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/11\/icon-user-safety-1.png\" alt=\"Safety\"><\/p>\n<p><a href=\"#safety\">Safety<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/11\/icon-high-flexibility.png\" alt=\"Flexibility\"><\/p>\n<p><a href=\"#flexibility\">Flexibility<\/a><\/p>\n<\/li>\n<li>\n<p>        <img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2023\/09\/complete-documentation.png\" alt=\"Full Documentation\"><\/p>\n<p><a href=\"#documentation\">Full Documentation<\/a><\/p>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<div><a class=\"uk-button uk-button-default\" href=\"#modal-quote\" uk-toggle>Request a quote <span uk-icon=\"icon: file-edit\"><\/span><\/a><\/p>\n<div id=\"modal-quote\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog uk-modal-body uk-margin-auto-vertical\">\n        \t<button class=\"uk-modal-close-outside\" type=\"button\" uk-close><\/button><\/p>\n<h3 class=\"uk-heading-bullet\">Request a quote<\/h3>\n\n\t\t\t\t\t\t<script>\n\t\t\t\t\t\t\twindow.hsFormsOnReady = window.hsFormsOnReady || [];\n\t\t\t\t\t\t\twindow.hsFormsOnReady.push(()=>{\n\t\t\t\t\t\t\t\thbspt.forms.create({\n\t\t\t\t\t\t\t\t\tportalId: 9033646,\n\t\t\t\t\t\t\t\t\tformId: \"f82ecb38-b753-4c96-b0da-a94dbda82e2d\",\n\t\t\t\t\t\t\t\t\ttarget: \"#hbspt-form-1778694925000-2303928520\",\n\t\t\t\t\t\t\t\t\tregion: \"na1\",\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t})});\n\t\t\t\t\t\t<\/script>\n\t\t\t\t\t\t<div class=\"hbspt-form\" id=\"hbspt-form-1778694925000-2303928520\"><\/div><\/div>\n<\/div>\n<\/div>\n<\/li>\n<li>\n<div><a class=\"uk-button uk-button-default\" href=\"\/us\/wp-content\/uploads\/sites\/3\/2024\/04\/BoneSTATION_Brochure_USA.pdf\">View Brochure <span uk-icon=\"icon: file-text\"><\/span><\/a><\/div>\n<\/li>\n<\/ul>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/01\/bonestation-unit.jpg\" alt=\"Bonestation Advanced System for Fixation and Decalcification of Bone Tissues\"><\/p>\n<ul>\n<li>\n<h3>INFRARED SENSOR<\/h3>\n<div>for automatic temperature control of the front platform<\/div>\n<\/li>\n<li>\n<h3>BACK PLATFORM<\/h3>\n<div>with a built-in magnetic stirrer<\/div>\n<\/li>\n<li>\n<h3>FRONT PLATFORM<\/h3>\n<div>with heating plate and magnetic stirrer<\/div>\n<\/li>\n<li>\n<h3>GLASS DISHES<\/h3>\n<div>to easily check specimen decalcification<\/div>\n<\/li>\n<li>\n<h3>PTFE COVERS <\/h3>\n<div>to contain vapours<\/div>\n<\/li>\n<li>\n<h3>TOUCHSCREEN TERMINAL<\/h3>\n<div>to set and customize process parameters<\/div>\n<\/li>\n<li>\n<h3>USB PORT<\/h3>\n<div>to download full process documentation<\/div>\n<\/li>\n<\/ul>\n<h2>Controlled Processes<\/h2>\n<div>The BoneSTATION allows for a controlled and standardized bone fixation and decalcification process, optimizing parameters in all steps to achieve excellent results in the shortest possible time.<\/div>\n<h2>Fixation<\/h2>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/fixation.jpg\" alt=\"Fixation\"><\/p>\n<div>The fixation step can be performed using both the platforms.<\/div>\n<ul>\n<li>\n<div>The back platform (no heat) features a built-in magnetic stirrer that <strong>ensures fresh fixative solution<\/strong> is continuously exposed to the sample.<\/div>\n<\/li>\n<li>\n<div>The front platform (heated) can reach temperatures up to 50\u00b0 C and this <strong>speeds up the fixation step<\/strong>.<br \/>It is equipped with a magnetic stirrer, which ensures the homogeneity of temperature throughout the solution, and an infrared sensor for automatic temperature control.<\/div>\n<\/li>\n<\/ul>\n<ul>\n<li>\n<h3>Compatible Fixative Reagents<\/h3>\n<div><a href=\"\/us\/products\/reagents\/#processing\">FineFIX<\/a>, Formalin<\/div>\n<\/li>\n<li>\n<h3>Setting Parameters<\/h3>\n<div>Reagent type, Time, Temperature<\/div>\n<\/li>\n<\/ul>\n<h2>Decalcification<\/h2>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/declacification.jpg\" alt=\"Declacification\"><\/p>\n<div>The decalcification step can be performed using both platforms. However, the <strong>heated platform enables users to expedite the process<\/strong>. In addition to even heat distribution, the stirrer maintains a constant flow of fresh decalcifier onto the bone surface and removes the saturated solution from around the specimen, accelerating the decalcification process.<\/div>\n<ul>\n<li>\n<h3>Compatible Decalcification Reagents<\/h3>\n<div><a href=\"\/us\/products\/reagents\/#decalcification\">MoL-DECALCIFIER<\/a>, EDTA 20% (max 50\u00b0C), formic acid 20% (max 50\u00b0C), acetic acid 20% (max 50\u00b0C), hydrochloric acid 10% (max 37\u00b0C), nitric acid 10% (max 37\u00b0C), trichloroacetic acid 10% (max 37\u00b0C)<\/div>\n<\/li>\n<li>\n<h3>Setting Parameters<\/h3>\n<div>Reagent type, Time, Temperature<\/div>\n<\/li>\n<\/ul>\n<h3>Productivity and Optimization<\/h3>\n<div>BoneSTATION enables outstanding productivity by concurrently run fixation and decalcification processes on its two platforms. Both processes are closely monitored, with continuous and detailed documentation of their parameters. The system doesn\u2019t require cleaning cycles or maintenance, <strong>allowing for higher productivity and eliminating any downtime.<\/strong><\/div>\n<div>\n<div>Recent reports have systematically <strong>investigated the effects of various fixation and decalcification agents<\/strong> on the quantity and quality of RNA and DNA recovered from bone biopsies. These reports concluded that <strong>the RNA and DNA yield and integrity are significantly reduced<\/strong> when strong acids (hydrochloric, nitric) are used in comparison with 12,5-14% EDTA and formic acid.<\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th>Fixatives<\/th>\n<th>DNA &#8211; Yield (ng)<\/th>\n<th>RNA &#8211; Yield (ng)<\/th>\n<th>Decal Time<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>14% EDTA<\/td>\n<td>67.8<\/td>\n<td>226.2<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>Formic<\/td>\n<td>41.5<\/td>\n<td>175.0<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>HNO<sub>3<\/sub><\/td>\n<td>11.4<\/td>\n<td>51.7<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<tr>\n<td>HCL\/EDTA<\/td>\n<td>5.3<\/td>\n<td>30.5<\/td>\n<td>2 hours<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><i>Analysis of the effect of various decalcification agents on the quality and quantity of nucleic acid (DNA and RNA) recovered from bone biopsies \u2013 Veena M. Singh et al. (2013)<\/i><\/p>\n<\/div>\n<div>\n<div>For this reason, the use of either EDTA or formic acid as \u201csoft\u201d decalcifiers is preferred, as they are more suitable for molecular studies. The decalcification process is further expedited when EDTA is utilized within a pH range of 7.2-7.4.<br \/>\nBased on this, Milestone has developed <strong><a href=\"\/us\/products\/reagents\/#decalcification\"> MoL-DECALCIFIER<\/a>, an innovative pure EDTA solution<\/strong>, based on a stoichiometric mixture of basic and tribasic EDTA, able to reach this pH value without requiring an additional acid\/base buffer. The combination of MoL-DECALCIFIER, temperature management, and the stirring function featured in the BoneSTATION significantly reduces decalcification times.<\/div>\n<\/div>\n<table>\n<thead>\n<tr>\n<th>Fixation<\/th>\n<th>Decalcification<\/th>\n<th>Temperature<\/th>\n<th>Total Time<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Formalin 10%<\/td>\n<td>MoL-DECALCIFIER<\/td>\n<td>\u00b0C<\/td>\n<td>Fixation + Decalcification<\/td>\n<\/tr>\n<tr>\n<td>4h<\/td>\n<td>36h<\/td>\n<td>27<\/td>\n<td>40h<\/td>\n<\/tr>\n<tr>\n<td>1h 30\u2019<\/td>\n<td>16h 30\u2019<\/td>\n<td>37<\/td>\n<td>18h<\/td>\n<\/tr>\n<tr>\n<td>1h<\/td>\n<td>4h<\/td>\n<td>50<\/td>\n<td>5h<\/td>\n<\/tr>\n<tr>\n<td>Formalin 10%<\/td>\n<td>Formic 10%<\/td>\n<td>\u00b0C<\/td>\n<td>Fixation + Decalcification<\/td>\n<\/tr>\n<tr>\n<td>4h<\/td>\n<td>4h<\/td>\n<td>27<\/td>\n<td>8h<\/td>\n<\/tr>\n<tr>\n<td>1h 30\u2019<\/td>\n<td>1h 30\u2019<\/td>\n<td>37<\/td>\n<td>3h<\/td>\n<\/tr>\n<tr>\n<td>1h<\/td>\n<td>4h<\/td>\n<td>50<\/td>\n<td>2h<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><i>BoneSTATION typical protocols for bone marrows (\u00d8 1.8mm)<\/i><\/p>\n<\/div>\n<div>Here is an example of results achieved using <a href=\"\/us\/products\/reagents\/#decalcification\"> MoL-DECALCIFIER<\/a> and BoneSTATION. A control multiplex-PCR: amplification of different sized genomic segments (100,200,300,400 bp) harboring single-copy genes (Biomed-2) (Institute for Pathology Charit\u00e9, Campus Mitte, Berlin, Germany).<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/01\/tonsil.png\" alt=\"Control multiplex-PCR\"><\/p>\n<div>M: size standard<br \/>\n1: Tonsil conventional<br \/>\n<strong>2, 4, 6: MoL-DECALCIEFIER<\/strong><br \/>\n3, 5, 7: Conventional<\/div>\n<div>\n<h3>Safety<\/h3>\n<div>BoneSTATION can accommodate various types of fixatives\/decalcifiers, including strong mineral acids such as HCl or HNO<sub>3<\/sub>, as all wetted surfaces are either glass or PTFE polymer.<br \/>\nThe system features <strong>closed vessels and fume condensation covers<\/strong>, and it must be installed under fume hood to further raise the safety during rack movement.<br \/>\nThe temperature of the reagent can be meticulously monitored using the temperature curve provided by the unit, ensuring <strong>controlled and safe processes<\/strong>.<\/div>\n<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/safety.jpg\" alt=\"Safety\"><br \/>\n<img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/flexibility.jpg\" alt=\"Flexibility\"><\/p>\n<div>\n<h3>Flexibility<\/h3>\n<div>Four acid-resistant rack configurations, each equipped with a built-in stirring bar, are available to <strong>accommodate bone specimens of varying sizes<\/strong>:<br \/>\n<\/p>\n<ul class=\"uk-list uk-list-divider uk-list-collapse\">\n<li><span uk-icon=\"icon: check\"><\/span> Rack for 30 standard cassettes<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Rack for 16 mega cassettes<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Rack for 6 supermega cassettes<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Rack with an internal divider<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div>\n<h3>Full Documentation<\/h3>\n<div>With BoneSTATION, every factor influencing the fixation and decalcification process is <strong>documented and stored in a logbook<\/strong>, which can be transferred to a USB stick and printed for quality assurance and compliance purposes. This includes:<br \/>\n<\/p>\n<ul class=\"uk-list uk-list-divider uk-list-collapse\">\n<li><span uk-icon=\"icon: check\"><\/span> Type of fixatives\/decalcification solutions used<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Time and date of fixation\/decalcification run<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Fixation phase duration and temperature<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Decalcification phase duration and temperature<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Events Log<\/li>\n<li><span uk-icon=\"icon: check\"><\/span> Saved runs<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p><img decoding=\"async\" src=\"\/us\/wp-content\/uploads\/2024\/02\/full-documentation.jpg\" alt=\"Full documentation\"><\/p>\n<div><a class=\"uk-button uk-button-default\" href=\"#modal-demo\" uk-toggle>Request a Virtual Demo <span uk-icon=\"icon: video-camera\"><\/span><\/a><\/p>\n<div id=\"modal-demo\" class=\"uk-flex-top\" uk-modal>\n<div class=\"uk-modal-dialog 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100px;}\\n\\n.el-element {background-color: rgba(0,0,0,0.3)}\\n\\n.uk-button {color: #000;}\",\"icon\":\"\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"default\",\"link_text\":\"\",\"margin\":\"default\",\"meta\":\"\n\n<h4><strong>Advanced System for Fixation and Decalcification of Bone Tissues<\\\/strong><\\\/h4>\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_padding\":\"default\",\"panel_style\":\"card-primary\",\"title\":\"BoneSTATION\",\"title_align\":\"top\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h1\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"2-3\"}}]}],\"name\":\"Hero\"},{\"type\":\"section\",\"props\":{\"animation\":\"slide-top-medium\",\"id\":\"solutions\",\"image_position\":\"center-center\",\"padding_remove_bottom\":false,\"padding_remove_top\":false,\"style\":\"default\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"xlarge\"},\"children\":[{\"type\":\"row\",\"props\":{\"layout\":\"1-2,1-2\",\"margin\":\"default\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"headline\",\"props\":{\"content\":\"Optimized and Efficient Bone Marrow Decalcification\\n\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_style\":\"h3\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"BoneSTATION is an innovative workstation designed for comprehensive control over the pre-analytical steps of bone tissues. It utilizes two work areas, one <strong>dedicated to the fixation process and<\\\/strong> another for the <strong>decalcification step<\\\/strong>, complete with glass dishes. 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Singh et al. (2013)<\\\/i><\\\/p>\",\"margin\":\"default\",\"maxwidth\":\"xlarge\",\"text_align\":\"center\",\"text_style\":\"small\"},\"name\":\"*frase Decal\"}]}]}]}]}]},{\"type\":\"row\",\"props\":{\"css\":\".uk-tile-muted {background-color: rgba(0, 0, 0, 0.1); border-radius: 20px;}\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"style\":\"tile-muted\"},\"children\":[{\"type\":\"fragment\",\"props\":{\"css\":\".uk-tile-muted {background-color: rgba(0, 0, 0, 0.1); border-radius: 20px;}\",\"margin\":\"default\"},\"children\":[{\"type\":\"row\",\"props\":{\"layout\":\"1-3,2-3\"},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"panel\",\"props\":{\"block_align\":\"center\",\"content\":\"For this reason, the use of either EDTA or formic acid as \\u201csoft\\u201d decalcifiers is preferred, as they are more suitable for molecular studies. The decalcification process is further expedited when EDTA is utilized within a pH range of 7.2-7.4. \\nBased on this, Milestone has developed <strong><a href=\\\"products\\\/reagents\\\/#decalcification\\\"> MoL-DECALCIFIER<\\\/a>, an innovative pure EDTA solution<\\\/strong>, based on a stoichiometric mixture of basic and tribasic EDTA, able to reach this pH value without requiring an additional acid\\\/base buffer. The combination of MoL-DECALCIFIER, temperature management, and the stirring function featured in the BoneSTATION significantly reduces decalcification times.\",\"content_column_breakpoint\":\"m\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"maxwidth\":\"xlarge\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"2-3\"},\"children\":[{\"type\":\"fs_table\",\"props\":{\"block_align\":\"center\",\"css\":\".el-element th {font-weight: bold; font-size: 16px;}\\n\\nthead {background-color: rgba(0, 0, 0, 0.1)}\\n.fs-table-row-0, 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page _PAGE_ of _PAGES_\",\"table_datatables_translation_infoEmpty\":\"No records available\",\"table_datatables_translation_infoFiltered\":\"(filtered from _MAX_ total records)\",\"table_datatables_translation_lengthMenu\":\"Display _MENU_ records per page\",\"table_datatables_translation_pagination_next\":\"Next\",\"table_datatables_translation_pagination_previous\":\"Previous\",\"table_datatables_translation_search\":\"Search\",\"table_datatables_translation_zeroRecords\":\"Nothing found - sorry\",\"table_head_image\":\"Image\",\"table_head_link\":\"Link\",\"table_head_text_1\":\"Fixation\",\"table_head_text_2\":\"Decalcification\",\"table_head_text_3\":\"Temperature\",\"table_head_text_4\":\"Total Time\",\"table_head_text_5\":\"Text 5\",\"table_head_text_6\":\"Text 6\",\"table_head_text_7\":\"Text 7\",\"table_head_text_8\":\"Text 8\",\"table_head_text_9\":\"Text 9\",\"table_head_title\":\"Standard\",\"table_hover\":true,\"table_justify\":false,\"table_meta\":\"\",\"table_meta_color\":\"primary\",\"table_meta_decoration\":\"divider\",\"table_meta_element\":\"div\",\"table_meta_limit_length\":\"80\",\"table_meta_margin\":\"remove\",\"table_meta_position\":\"below-table-title\",\"table_meta_style\":\"h3\",\"table_order\":\"4\",\"table_responsive\":\"overflow\",\"table_size\":\"small\",\"table_style\":\"divider\",\"table_title\":\"\",\"table_title_element\":\"h2\",\"table_title_grid_breakpoint\":\"m\",\"table_title_grid_width\":\"1-2\",\"table_title_limit_length\":\"80\",\"table_title_position\":\"top\",\"table_vertical_align\":true,\"table_width_image\":\"shrink\",\"table_width_image_custom\":\"100\",\"table_width_link\":\"shrink\",\"table_width_link_custom\":\"100\",\"table_width_text_1\":\"shrink\",\"table_width_text_1_custom\":\"100\",\"table_width_text_2\":\"shrink\",\"table_width_text_2_custom\":\"100\",\"table_width_text_3\":\"shrink\",\"table_width_text_3_custom\":\"100\",\"table_width_text_4\":\"shrink\",\"table_width_text_4_custom\":\"100\",\"table_width_text_5\":\"shrink\",\"table_width_text_5_custom\":\"100\",\"table_width_text_6\":\"shrink\",\"table_width_text_6_custom\":\"100\",\"table_width_text_7\":\"shrink\",\"table_width_text_7_custom\":\"100\",\"table_width_text_8\":\"shrink\",\"table_width_text_8_custom\":\"100\",\"table_width_text_9\":\"shrink\",\"table_width_text_9_custom\":\"100\",\"table_width_title\":\"shrink\",\"table_width_title_custom\":\"100\",\"text_1_align\":\"center\",\"text_1_limit_length\":\"10\",\"text_1_style\":\"h5\",\"text_2_align\":\"center\",\"text_2_limit_length\":\"20\",\"text_2_style\":\"h5\",\"text_3_align\":\"center\",\"text_3_limit_length\":\"30\",\"text_3_style\":\"h5\",\"text_4_align\":\"center\",\"text_4_limit_length\":\"40\",\"text_4_style\":\"h5\",\"text_5_align\":\"center\",\"text_5_limit_length\":\"50\",\"text_5_style\":\"h5\",\"text_6_align\":\"center\",\"text_6_limit_length\":\"60\",\"text_6_style\":\"h5\",\"text_7_align\":\"center\",\"text_7_limit_length\":\"70\",\"text_7_style\":\"h5\",\"text_8_align\":\"center\",\"text_8_limit_length\":\"80\",\"text_8_style\":\"h5\",\"text_9_align\":\"center\",\"text_9_limit_length\":\"80\",\"text_9_style\":\"h5\",\"title_limit_length\":\"80\",\"title_style\":\"h5\"},\"children\":[{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"Formalin 10%\",\"text_2\":\"MoL-DECALCIFIER\",\"text_3\":\"\\u00b0C\",\"text_4\":\"Fixation + Decalcification\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"4h\",\"text_2\":\"36h\",\"text_3\":\"27\",\"text_4\":\"40h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h 30\\u2019\",\"text_2\":\"16h 30\\u2019\",\"text_3\":\"37\",\"text_4\":\"18h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h\",\"text_2\":\"4h\",\"text_3\":\"50\",\"text_4\":\"5h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"Formalin 10%\",\"text_2\":\"Formic 10%\",\"text_3\":\"\\u00b0C\",\"text_4\":\"Fixation + Decalcification\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"4h\",\"text_2\":\"4h\",\"text_3\":\"27\",\"text_4\":\"8h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h 30\\u2019\",\"text_2\":\"1h 30\\u2019\",\"text_3\":\"37\",\"text_4\":\"3h\",\"title\":\"\"}},{\"type\":\"fs_table_item\",\"props\":{\"label_custom_color\":\"#000000\",\"text_1\":\"1h\",\"text_2\":\"4h\",\"text_3\":\"50\",\"text_4\":\"2h\",\"title\":\"\"}}]},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"\n\n<p><i>BoneSTATION typical protocols for bone marrows (\\u00d8 1.8mm)<\\\/i><\\\/p>\",\"margin\":\"default\",\"text_align\":\"center\",\"text_style\":\"small\"},\"name\":\"*frase Decal\"}]}]}]}]}]},{\"type\":\"row\",\"props\":{\"column_gap\":\"medium\",\"id\":\"safety\",\"layout\":\"1-2,1-2\",\"margin\":\"large\",\"margin_remove_top\":false,\"row_gap\":\"large\",\"vertical_align\":true},\"children\":[{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"text\",\"props\":{\"block_align\":\"center\",\"column_breakpoint\":\"m\",\"content\":\"Here is an example of results achieved using <a href=\\\"products\\\/reagents\\\/#decalcification\\\"> MoL-DECALCIFIER<\\\/a> and BoneSTATION. A control multiplex-PCR: amplification of different sized genomic segments (100,200,300,400 bp) harboring single-copy genes (Biomed-2) (Institute for Pathology Charit\\u00e9, Campus Mitte, Berlin, Germany).\",\"margin\":\"default\",\"maxwidth\":\"2xlarge\",\"text_align\":\"left\"}}]},{\"type\":\"column\",\"props\":{\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-2\"},\"children\":[{\"type\":\"image\",\"props\":{\"image\":\"wp-content\\\/uploads\\\/2024\\\/01\\\/tonsil.png\",\"image_alt\":\"Control multiplex-PCR\",\"image_svg_color\":\"emphasis\",\"image_width\":\"600\",\"margin\":\"default\",\"text_align\":\"center\"}},{\"type\":\"text\",\"props\":{\"column_breakpoint\":\"m\",\"content\":\"M: size standard<br \\\/>\\n1: Tonsil conventional<br \\\/>\\n<strong>2, 4, 6: MoL-DECALCIEFIER<\\\/strong><br \\\/>\\n3, 5, 7: Conventional\",\"margin\":\"default\",\"text_align\":\"center\",\"text_style\":\"small\"}}]}]}]},{\"name\":\"safety - flexibility - documentation\",\"type\":\"section\",\"props\":{\"id\":\"features\",\"image_position\":\"center-center\",\"image_size\":\"cover\",\"padding_remove_top\":false,\"style\":\"muted\",\"title_breakpoint\":\"xl\",\"title_position\":\"top-left\",\"title_rotation\":\"left\",\"vertical_align\":\"middle\",\"width\":\"xlarge\"},\"children\":[{\"type\":\"row\",\"props\":{\"column_gap\":\"large\",\"divider\":false,\"id\":\"safe\",\"layout\":\"1-3,1-3,1-3\",\"margin\":\"default\",\"margin_remove_bottom\":true,\"row_gap\":\"large\",\"vertical_align\":true},\"children\":[{\"type\":\"column\",\"props\":{\"id\":\"safety\",\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"vertical_align\":\"middle\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"panel\",\"props\":{\"animation\":\"slide-top-medium\",\"block_align\":\"center\",\"content\":\"BoneSTATION can accommodate various types of fixatives\\\/decalcifiers, including strong mineral acids such as HCl or HNO<sub>3<\\\/sub>, as all wetted surfaces are either glass or PTFE polymer. \\nThe system features <strong>closed vessels and fume condensation covers<\\\/strong>, and it must be installed under fume hood to further raise the safety during rack movement. \\nThe temperature of the reagent can be meticulously monitored using the temperature curve provided by the unit, ensuring <strong>controlled and safe processes<\\\/strong>.\",\"content_column_breakpoint\":\"m\",\"content_margin\":\"small\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"Safety\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}},{\"type\":\"image\",\"props\":{\"class\":\"uk-visible@m\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/safety.jpg\",\"image_alt\":\"Safety\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\"},\"name\":\"Image for M\\\/L only\"}]},{\"type\":\"column\",\"props\":{\"id\":\"flexibility\",\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"image\",\"props\":{\"class\":\"uk-visible@m\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/flexibility.jpg\",\"image_alt\":\"Flexibility\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\"},\"name\":\"Image for M\\\/L only\"},{\"type\":\"panel\",\"props\":{\"animation\":\"slide-bottom-medium\",\"block_align\":\"center\",\"content\":\"Four acid-resistant rack configurations, each equipped with a built-in stirring bar, are available to <strong>accommodate bone specimens of varying sizes<\\\/strong>:\\n<br \\\/>\\n\n\n<ul class=\\\"uk-list uk-list-divider uk-list-collapse\\\">\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Rack for 30 standard cassettes<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Rack for 16 mega cassettes<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Rack for 6 supermega cassettes<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Rack with an internal divider<\\\/li>\\n<\\\/ul>\",\"content_column_breakpoint\":\"m\",\"content_margin\":\"small\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"Flexibility\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}}]},{\"type\":\"column\",\"props\":{\"id\":\"documentation\",\"image_position\":\"center-center\",\"position_sticky_breakpoint\":\"m\",\"width_medium\":\"1-3\"},\"children\":[{\"type\":\"panel\",\"props\":{\"animation\":\"slide-top-medium\",\"block_align\":\"center\",\"content\":\"With BoneSTATION, every factor influencing the fixation and decalcification process is <strong>documented and stored in a logbook<\\\/strong>, which can be transferred to a USB stick and printed for quality assurance and compliance purposes. This includes:\\n<br \\\/>\\n\n\n<ul class=\\\"uk-list uk-list-divider uk-list-collapse\\\">\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Type of fixatives\\\/decalcification solutions used<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Time and date of fixation\\\/decalcification run<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Fixation phase duration and temperature<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Decalcification phase duration and temperature<\\\/li>\\n     \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Events Log<\\\/li>\\n    \n\n<li><span uk-icon=\\\"icon: check\\\"><\\\/span> Saved runs<\\\/li>\\n<\\\/ul>\",\"content_column_breakpoint\":\"m\",\"content_margin\":\"small\",\"icon_width\":80,\"image_align\":\"top\",\"image_grid_breakpoint\":\"m\",\"image_grid_width\":\"1-2\",\"image_svg_color\":\"emphasis\",\"link_style\":\"text\",\"link_text\":\"\",\"margin\":\"\",\"meta_align\":\"below-title\",\"meta_element\":\"div\",\"meta_style\":\"text-meta\",\"panel_card_size\":\"large\",\"text_align\":\"left\",\"title\":\"Full Documentation\",\"title_align\":\"top\",\"title_decoration\":\"bullet\",\"title_element\":\"h3\",\"title_grid_breakpoint\":\"m\",\"title_grid_width\":\"1-2\",\"title_hover_style\":\"reset\",\"title_style\":\"h3\"}},{\"type\":\"image\",\"props\":{\"class\":\"uk-visible@m\",\"image\":\"wp-content\\\/uploads\\\/2024\\\/02\\\/full-documentation.jpg\",\"image_alt\":\"Full documentation\",\"image_svg_color\":\"emphasis\",\"margin\":\"default\"},\"name\":\"Image for M\\\/L 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